Rat Brain Cells Control a Robot Body
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Author:  QuiescentWonder [ Thu Aug 14, 2008 4:01 am ]
Post subject:  Rat Brain Cells Control a Robot Body

This is [censored] cool. Follow the link for a video. Reminds me of this thing from Sealab 2021. Also reminds me of this (warning, one profane word) comment about New Scientist.

From Sealab 2021 wrote:
Derek ‘Stormy’ Waters: Okay, okay. So, say I put my brain in a robot body and there’s a war. Robots versus humans. What side am I on?

Debbie DuPree: Humans! You have a human brain.

Sparks: But… the humans discriminate against you. You can’t even vote!

Marco: We’d better not have to live on a reservation. That would really chap my caboose.

Captain Murphy: Yeah, but… nobody knows you’re a robot. You look the same.
Debbie DuPree: Uh, uh. Dogs know. That’s how the humans hunt you.

Derek ‘Stormy’ Waters: They’re gonna’ hunt me? For sport?

Marco: That’s why we have to CRUSH mankind! So you might as well get on board for the big win, Stormy.

Source: ... obots.html

AFTER buttoning up a lab coat, snapping on surgical gloves and spraying them with alcohol, I am deemed sanitary enough to view a robot's control system up close. Without such precautions, any fungal spores on my skin could infect it. "We've had that happen. They just stop working and die off," says Mark Hammond, the system's creator.

This is no ordinary robot control system - a plain old microchip connected to a circuit board. Instead, the controller nestles inside a small pot containing a pink broth of nutrients and antibiotics. Inside that pot, some 300,000 rat neurons have made - and continue to make - connections with each other.

As they do so, the disembodied neurons are communicating, sending electrical signals to one another just as they do in a living creature. We know this because the network of neurons is connected at the base of the pot to 80 electrodes, and the voltages sparked by the neurons are displayed on a computer screen.

It's these spontaneous electrical patterns that researchers at the University of Reading in the UK want to harness to control a robot. If they can do so reliably, by stimulating the neurons with signals from sensors on the robot and using the neurons' response to get the robots to respond, they hope to gain insights into how brains function. Such insights might help in the treatment of conditions like Alzheimer's, Parkinson's disease and epilepsy.

"We're trying to understand what is going on inside this brain material that could have direct implications for human health," says Kevin Warwick, Reading's head of cybernetics, who is running the project with Hammond and Ben Whalley, both neuroscientists.

The team are far from alone in this aim. At a July conference on in-vitro recording technology in Reutlingen, Germany, teams from around the world presented projects on culturing brain material and plugging it into simulations and robots, or "animats" as they are known.

To create the "brain", the neural cortex from a rat fetus is surgically removed and disassociating enzymes applied to it to disconnect the neurons from each other. The researchers then deposit a slim layer of these isolated neurons into a nutrient-rich medium on a bank of electrodes, where they start reconnecting. They do this by growing projections that reach out to touch the neighbouring neurons. "It's just fascinating that they do this," says Steve Potter of the Georgia Institute of Technology in Atlanta, who pioneered the field of neurally controlled animats. "Clearly brain cells have evolved to reconnect under almost any circumstance that doesn't kill them."

After about five days, patterns of electrical activity can be detected as the neurons transmit signals around what has become a very dense mesh of axons and dendrites. The neurons seem to be randomly firing, producing pulses of voltage known as action potentials. Often, though, many or all of them will fire in unison, a phenomenon known as "bursting".

There are various views on what these bursts are. Some see them as pathological activity - akin to what happens in epilepsy - while others see them as the neural network expressing a stored memory. "I interpret them as seizure-like behaviour," says Potter. "I think the bursting is a function of sensory deprivation."

Like a creature with no limbs or senses, the cut-down brain is simply bursting out of boredom, says Whalley. "With no structured sensory input the hypothesis is that you get arbitrarily random and quite often detrimental activity because all these cells are asking for some kind of direction."

To test this notion, Potter's team "sprinkled" pulses of electricity across a number of contacts on the multi-electrode array (MEA), to simulate sensory inputs, and managed to significantly quell bursting activity. "It seems that sensory input is setting the background level of activity inside the brain," says Potter.

These results have encouraged the researchers to begin investigating disease pathology with robots controlled by the cortical cultures. If they can make a robot do something repeatedly by sending signals to the culture, and then alter the brain chemically, electrically or physically to upset this controllability, they hope to be able to work out some causes and effects that throw light on disorders such as Alzheimer's.

To do this, Whalley's colleagues Dimitris Xydas and Julia Downes started by connecting a culture to an ultrasound sensor in a wheeled robot. They then record the spikes of voltage produced at points within the culture when signals from the sensor are sent to it. When they find an area that fires consistently when the sensor input reaches it, those signals can be picked up by an electrode and used to, say, make the robot avoid an obstruction. For example, if the ultrasound sensor indicates "wall dead ahead" with a 1 volt signal, and a certain knot of neurons in the culture always generates a 100-microvolt action potential when that happens, the latter signal can be used to make the robot steer right or left to avoid the wall.

To do this, of course, they need to connect their brain culture to the robot. Because it is living material, it needs to be kept at body temperature, so the control system is placed in a temperature-controlled cabinet the size of a microwave oven and communicates with the robot over a Bluetooth radio link.

The robot then whirrs around a wooden corral, and in about 80 per cent of its interactions with the walls manages to successfully avoid them. The researchers now plan to plot neural connections before and after such extended journeys to see if the connections are strengthening, says Downes.

At Georgia Tech, Potter has achieved similar results, getting his mobile robot to avoid obstacles 90 per cent of the time. He is hoping the research will help doctors to find ways to retrain or bypass malfunctioning neuronal circuits in people with epilepsy, and he is also starting work on Alzheimer's.

The first step towards this, though, is to find a way to train the neurons into a more permanent state of reacting to sensor inputs at the right times. In a paper to be published in the Journal of Neural Engineering, Potter describes a novel training system for these mini brains.

What he has found is that a sequence of electric pulses applied to up to six electrodes on an MEA act as a kind of "mode switch" for the culture, changing its behaviour from being good at, say, steering a robot in a straight line to manoeuvring to avoid an obstacle. But because all cultures are different, he doesn't know which pulse sequences will work best for each of them. So he randomly generates 100 different sequences - called pattern training stimuli - for each culture and lets a computer work out which ones produce the best neural connections to make a virtual robot move in a desired direction.
"A sequence of electric pulses can make the brain culture change the robot's behaviour"

After the selected stimuli have been applied a few times, certain behaviours become embedded in the culture for some hours. In other words, the culture has been taught what to do. "It's like training an animal to do something by gradual increments," Potter says.

The Reading team are now planning to study whether particular parts of the culture, rather than all of it, can be more useful for performing certain tasks. They also plan to study whether the culture should be embodied in a robot early on. At the moment, they wait three to five weeks until a culture is mature before applying any sensory input. This might amount to trying to get a sensory-deprived "insane" culture to learn, says Whalley.

This work will hopefully contribute to our knowledge of how brains work, but its potential should not be exaggerated, says Potter. "This system is a model. Everything it does is merely similar to what goes on in a brain, it's not really the same thing. We can learn about the brain - but it may mislead us."

Warwick agrees, but believes it will be useful. "If this kind of work can make a 1 per cent difference to the life of an Alzheimer's patient it will be worth it," he says.

Author:  Frozenport [ Thu Aug 14, 2008 4:53 am ]
Post subject: 

I suppose the thing of value here is the technical aspect; connecting cells to electrical circuts

The actual setup is very little more then a switch; almost no "thinking" is actually going on :D

Author:  QuiescentWonder [ Thu Aug 14, 2008 5:21 am ]
Post subject: 

Well, I'm sure you noticed by reading the article that it has a bit more value than just connecting circuits to brain cells. I mean, they form electrical circuits themselves, it's how they communicate. I wasn't really surprised by this, just amazed that someone actually did it.

What makes you think that they aren't "thinking"? I'm not sure it's even worth discussing to that degree unless someone here has some sort of degree or higher knowledge in something that relates to this?

Author:  inxsfan92 [ Thu Aug 14, 2008 6:36 am ]
Post subject: 


'nuff said

Author:  Frozenport [ Fri Aug 15, 2008 5:32 am ]
Post subject: 

QuiescentWonder wrote:
What makes you think that they aren't "thinking"? I'm not sure it's even worth discussing to that degree unless someone here has some sort of degree or higher knowledge in something that relates to this?

I have some knowledge in my major; (which is electrical engineering)...

There is nothing special in "how they communicate" its their natural mechanical reaction. It is similar to heart muscles cells in a petri dish that will pulsate without an actual heart.

There are many exciting things happening in the field of engineering, such as the recent developments in metamaterials... I'm a little irked at how this steals the spotlight from more interesting news stories...

Author:  QuiescentWonder [ Fri Aug 15, 2008 5:58 am ]
Post subject: 

I did a quick little look around and the way that most places define "thinking" makes it seem like this is considered thinking. However, by the definitions they have a computer could also be "thinking". Then I came across something that said "thinking is a higher cognitive function." I'll believe the latter, I still think this is incredibly interesting.

Author:  ___ [ Fri Aug 15, 2008 11:38 am ]
Post subject: 

inxsfan92 wrote:

'nuff said


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